Welcome to The Bisker Lab at Tel Aviv University

Optical Nano Sensors for Biomarkers

We use fluorescent single-walled carbon nanotubes as optical sensors in the near-infrared. We aim to detect target analytes and monitor active processes in biological systems for biomedical applications. We have demonstrated the detection of insulin secreted by β-Cells, cellular oncometabolite, and other biomarkers.

Real-Time Monitoring of Enzymatic Activity

Tailored functionalization of fluorescent single-walled carbon nanotubes is used for monitoring enzymatic activity, in real-time, with spatial and temporal resolution. Such a platform is used, for example, for sensing the activity of cholinesterase, esterase, amidase, and coagulation factors.

Super Resolution Imaging in the Near-Infrared

We utilize the advantages of deep learning and convolutional neural networks, along with the super-resolution radial fluctuation (SRRF) algorithm for network training, to offer a fast, parameter-free computational method for enhancing the spatial resolution of nIR fluorescence images of single-walled carbon nanotubes.

Sensing of Metal Contaminants

We demonstrate a multicomponent system of single-walled carbon nanotubes functionalized by bio-inspired materials that serves as a metal-ion scavenging platform that concurrently reports on metal binding with optical signal transduction.

Nonequilibrium self-assembly

We set out to explore the added benefits achieved by nonequilibrium driving with the goal of identifying distinctive collective phenomena that emerge in this regime

Stochastic Thermodynamics

Living systems constantly dissipate energy, while consuming chemical fuel at the molecular level. Our goal is to find new methods for estimating the amount of dissipation by identifying time-irreversibility signatures in the dynamics

Gili Bisker​

Principal Investigator

Adi Hendler​

Lab Manager

Myriam Brunot

Admin

Dotan Kamber​

Research Associate

Verena Wulf​

Research Associate

Srestha Basu

Postdoc

Shubhadeep Nag

Postdoc

Michael Faran

PhD Student

Shirel Kleiner

PhD Student

Gabriel Petresky

MSc Student

Geffen Rosenberg

MSc Student

Galia Shai Basson

Undergraduate Student

Itamar Magar

Undergraduate Student

Shaked Elimelech

Undergraduate Student

Marie Martyanova

Undergraduate Student

Gali Gurenko

Undergraduate Student

Raz Elkayam

Undergraduate Student

Tamar Duvdevani

Undergraduate Student

Max Klaber

Undergraduate Student

Ron Nekrashevich

Undergraduate Student

Selected publications

Inferring broken detailed balance in the absence of observable currents
Ignacio A. Martínez*, Gili Bisker*, Jordan M. Horowitz & Juan M. R. Parrondo
Nature Communications (2019)

Nonequilibrium associative retrieval of multiple stored self-assembly targets
Gili Bisker and Jeremy L England
Proceedings of the National Academy of Sciences, (2018)

Insulin detection using a corona phase molecular recognition site on single-walled carbon nanotubes
Gili Bisker*, Naveed A. Bakh*, Michael A. Lee, Jiyoung Ahn, Minkyung Park, Ellen B. O’Connell, Nicole M. Iverson, and Michael S. Strano
ACS Sensors, 3(2), 367-377 (2018)

Hierarchical Bounds on Entropy Production Inferred from Partial Information
Gili Bisker, Matteo Polettini, Todd R. Gingrich, and Jordan M. Horowitz
Journal of Statistical Mechanics: Theory and Experiment, (9), 093210 (2017)

Protein Targeted Corona Phase Molecular Recognition
Gili Bisker, Juyao Dong, Hoyoung D. Park, Nicole M. Iverson, Jiyoung Ahn, Justin T. Nelson, Markita P. Landry, Sebastian Kruss, and Michael S. Strano
Nature Communications, 7 (2016)

Dissipate your way to self-assembly
Gili Bisker
Nature Physics (2020)

Monitoring the Formation of Fibrin Clots as Part of the Coagulation Cascade Using Fluorescent Single-Walled Carbon Nanotubes
Efrat Gerstman, Adi Hendler-Neumark, Verena Wulf, and Gili Bisker
ACS Applied Materials & Interfaces (2023)

Multicomponent System of Single‐Walled Carbon Nanotubes Functionalized with a Melanin‐Inspired Material for Optical Detection and Scavenging of Metals
Verena Wulf, Ella Bichachi, Adi Hendler-Neumark, Tlalit Massarano, Avigail Baruch Leshem, Ayala Lampel, and Gili Bisker
Advanced Functional Materials (2022)

Dendron–Polymer Hybrids as Tailorable Responsive Coronae of Single-Walled Carbon Nanotubes
Verena Wulf, Gadi Slor, Parul Rathee, Roey J. Amir, and Gili Bisker
ACS Nano (2021)

Oncometabolite Fingerprinting Using Fluorescent Single-Walled Carbon Nanotubes
Dean Amir, Adi Hendler-Neumark, Verena Wulf,Roni Ehrlich, and Gili Bisker
Advanced Materials Interfaces (2021)

Optical Nanosensors for Real-Time Feedback on Insulin Secretion by β-Cells
Roni Ehrlich, Adi Hendler-Neumark, Verena Wulf, Dean Amir, and Gili Bisker
Small (2021)

In the Media

How can we detect nonequilibrium in complex systems?

Body bionics: how the next generation of biosensors could revolutionise drug delivery

Nanotube implants show diagnostic potential

Synthetic antibody detects proteins

Visit us

Broadcom Building, Room 206

Tel-Aviv University

Tel Aviv 69978

Israel

Funding

Contact us if you are interested in joining our team. Please send your CV and a short description of your research interests. We have open positions at all levels​.