Welcome to The Bisker Lab at Tel Aviv University
Optical Nano Sensors for Biomarkers
We use fluorescent single-walled carbon nanotubes as optical sensors in the near-infrared. We aim to detect target analytes and monitor active processes in biological systems for biomedical applications. We have demonstrated the detection of insulin secreted by β-Cells, cellular oncometabolite, and other biomarkers.
Real-Time Monitoring of Enzymatic Activity
Tailored functionalization of fluorescent single-walled carbon nanotubes is used for monitoring enzymatic activity, in real-time, with spatial and temporal resolution. Such a platform is used, for example, for sensing the activity of cholinesterase, esterase, amidase, and coagulation factors.
Super Resolution Imaging in the Near-Infrared
We utilize the advantages of deep learning and convolutional neural networks, along with the super-resolution radial fluctuation (SRRF) algorithm for network training, to offer a fast, parameter-free computational method for enhancing the spatial resolution of nIR fluorescence images of single-walled carbon nanotubes.
Sensing of Metal Contaminants
We demonstrate a multicomponent system of single-walled carbon nanotubes functionalized by bio-inspired materials that serves as a metal-ion scavenging platform that concurrently reports on metal binding with optical signal transduction.
Nonequilibrium self-assembly
We set out to explore the added benefits achieved by nonequilibrium driving with the goal of identifying distinctive collective phenomena that emerge in this regime
Stochastic Thermodynamics
Living systems constantly dissipate energy, while consuming chemical fuel at the molecular level. Our goal is to find new methods for estimating the amount of dissipation by identifying time-irreversibility signatures in the dynamics
Gili Bisker
Principal Investigator
Adi Hendler
Lab Manager
Myriam Brunot
Admin
Dotan Kamber
Research Associate
Verena Wulf
Research Associate
Srestha Basu
Postdoc
Shubhadeep Nag
Postdoc
Michael Faran
PhD Student
Shirel Kleiner
PhD Student
Gabriel Petresky
MSc Student
Geffen Rosenberg
MSc Student
Galia Shai Basson
Undergraduate Student
Itamar Magar
Undergraduate Student
Gali Gurenko
Undergraduate Student
Shaked Elimelech
Undergraduate Student
Marie Martyanova
Undergraduate Student
Raz Elkayam
Undergraduate Student
Tamar Duvdevani
Undergraduate Student
Selected publications
Inferring broken detailed balance in the absence of observable currents
Ignacio A. Martínez*, Gili Bisker*, Jordan M. Horowitz & Juan M. R. Parrondo
Nature Communications (2019)
Nonequilibrium associative retrieval of multiple stored self-assembly targets
Gili Bisker and Jeremy L England
Proceedings of the National Academy of Sciences, (2018)
Insulin detection using a corona phase molecular recognition site on single-walled carbon nanotubes
Gili Bisker*, Naveed A. Bakh*, Michael A. Lee, Jiyoung Ahn, Minkyung Park, Ellen B. O’Connell, Nicole M. Iverson, and Michael S. Strano
ACS Sensors, 3(2), 367-377 (2018)
Hierarchical Bounds on Entropy Production Inferred from Partial Information
Gili Bisker, Matteo Polettini, Todd R. Gingrich, and Jordan M. Horowitz
Journal of Statistical Mechanics: Theory and Experiment, (9), 093210 (2017)
Protein Targeted Corona Phase Molecular Recognition
Gili Bisker, Juyao Dong, Hoyoung D. Park, Nicole M. Iverson, Jiyoung Ahn, Justin T. Nelson, Markita P. Landry, Sebastian Kruss, and Michael S. Strano
Nature Communications, 7 (2016)
Dissipate your way to self-assembly
Gili Bisker
Nature Physics (2020)
Monitoring the Formation of Fibrin Clots as Part of the Coagulation Cascade Using Fluorescent Single-Walled Carbon Nanotubes
Efrat Gerstman, Adi Hendler-Neumark, Verena Wulf, and Gili Bisker
ACS Applied Materials & Interfaces (2023)
Multicomponent System of Single‐Walled Carbon Nanotubes Functionalized with a Melanin‐Inspired Material for Optical Detection and Scavenging of Metals
Verena Wulf, Ella Bichachi, Adi Hendler-Neumark, Tlalit Massarano, Avigail Baruch Leshem, Ayala Lampel, and Gili Bisker
Advanced Functional Materials (2022)
Dendron–Polymer Hybrids as Tailorable Responsive Coronae of Single-Walled Carbon Nanotubes
Verena Wulf, Gadi Slor, Parul Rathee, Roey J. Amir, and Gili Bisker
ACS Nano (2021)
In vivo imaging of fluorescent single-walled carbon nanotubes within C. elegans nematodes in the near-infrared window
Adi Hendler-Neumark, Verena Wulf, and Gili Bisker
Materials Today Bio (2021)
Oncometabolite Fingerprinting Using Fluorescent Single-Walled Carbon Nanotubes
Dean Amir, Adi Hendler-Neumark, Verena Wulf,Roni Ehrlich, and Gili Bisker
Advanced Materials Interfaces (2021)
Optical Nanosensors for Real-Time Feedback on Insulin Secretion by β-Cells
Roni Ehrlich, Adi Hendler-Neumark, Verena Wulf, Dean Amir, and Gili Bisker
Small (2021)
In the Media
How can we detect nonequilibrium in complex systems?
Body bionics: how the next generation of biosensors could revolutionise drug delivery
Nanotube implants show diagnostic potential
Synthetic antibody detects proteins
Funding
Contact us if you are interested in joining our team. Please send your CV and a short description of your research interests. We have open positions at all levels.